USC vs Illinois Prediction, Picks & Odds | 27 Sep 2025

By Peter Taylor, NCAAF Analyst | Published: 1 day ago | 4 min read
Southern California Trojans (USC)
American Football NCAAF Memorial Stadium Sun 28 Sep 00:00
Illinois Fighting Illini
  1. Prediction
  2. Bet Builder
  3. Odds
  4. Player Props
  5. Stats
  6. Standings

College Football Betting Preview: USC vs Illinois

USC square off against Illinois in this NCAAF Week 5 matchup at Memorial Stadium, with kickoff scheduled for 00:00 on Sunday 28 September. Our betting preview features expert predictions, picks, the latest betting odds and H2H stats.

Will Illini Stay in Reach of the Favorites?

The market might have underrated Illinois and 1.91 makes appeal considering they are +6.5 on the spread. Bet on them to cover the line against Illinois.

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USC Landed Victory in Last Game

USC Trojans have won their previous four games. The latest was a 45-31 home triumph at LA Memorial Coliseum against Michigan State Spartans.

Illinois Fighting Illini have secured back-to-back home victories. Their last game was on the road and a 63-10 loss occurred against Indiana Hoosiers at Memorial Stadium.

Quarterbacks

Jayden Maiava
Luke Altmyer

USC vs Illinois Prediction & Picks

Prepare for USC vs Illinois with our expert betting guide featuring a trusted match prediction, likely scoreline, key player props and a well-crafted bet builder.

Game Prediction

The underdogs look a great play at +6.5 on the spread. Illinois could beat their opponents and the 1.91 about this college football pick makes lots of appeal.

The CFB handicappers at jeetwin-vip.com start by analyzing recent form and staying on top of injury news before making any picks. From there, we interpret the story the stats are telling to help shape our predictions.

Key USC vs Illinois stats:

  • The +6.5 line has been covered by Illinois in 4 consecutive games at home.
  • The +6.5 line has been covered by Illinois in 9 of their last 10 games at home.
  • The +6.5 line has been covered by Illinois in 16 of their last 20 games.
  • The -6.5 line hasn’t been covered by USC in 4 of their last 5 games on the road.
  • The -6.5 line hasn’t been covered by USC in 8 of their last 10 games on the road.

Illini +6.5 Probability

The top betting apps make it a 52.4% chance that our pick is settled as a winner. However, our cappers have this figure closer to 60% based on their in-depth research. That means we are regarding it as a value wager.

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Best Bet

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Published 06:26, 26 September 2025

Player Prop Picks

Top Pick: Kaden Feagin Anytime TD

Kaden Feagin (Illini) can be backed at 1.74 to score in the red zone. We think this is the pick of the player props, with generous odds available when it comes to backing him to score a touchdown at any time.

Latest Kaden Feagin Player Prop Odds
Touchdown
Rushing Yards
 Luke Altmyer Over 232.5 Passing Yards

The odds for Luke Altmyer (Illini) to surpass 232.5 passing yards are 1.88. We're confident in him covering the QB Passing Yards line and hitting our Over bet.

Latest Luke Altmyer Player Prop Odds
Touchdown
Passing Yards
Rushing Yards

Same Game Parlay Picks

Spread Illinois +6.5
Totals Under 60.5
Anytime Touchdown Kaden Feagin

We’ve got a same game parlay with three options: Illinois +6.5, Under 60.5 points and Kaden Feagin (Illinois) to record a touchdown.

There are many options when you place a same game parlay. You can go through the football lines and identify your favorite outcomes before combining the odds on the bet slip. Personalised betting doesn’t come any better.

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Correct Score Prediction

USC USC logo 27 - 28 Illinois logo Illinois

There’s every chance that this is going to be a close matchup and we’ll have a play on the Illini achieving a 28-27 winning scoreline. Hopefully this can go close.

USC vs Illinois Odds

The odds and lines are updated on a frequent basis. You might therefore find that they are different to the ones listed for the betting predictions and bet builder tips.

Books Giving USC Plenty of Respect

With a 71% chance of securing victory, USC are favorites for this college game and the sportsbooks have them at betting odds of 1.41. For those wanting to back Illinois, you will find 2.98 about the underdogs.

The spread is currently 6.5, with the total points line at 60.5. There is no denying the popularity of wagering on the Totals. Those that want to back Under 60.5 can find odds of 1.95 available.

College football fans are spoilt for choice thanks to the wide range of game lines and team props which are available for every clash on the coupon. Head to the top betting sites and find the best value picks.

Moneyline
Point Spread
Total Points

Waymond Jordan Favorite to Be First TD Scorer

Waymond Jordan is priced at 5.90 when it comes to First TD Scorer. He’s the favorite and also available at odds of 1.53 to score a touchdown at anytime.

Touchdown

Waymond Jordan (USC)
Makai Lemon (USC)
Kaden Feagin (Illini)
Eli Sanders (USC)

Receiving Yards

Makai Lemon (USC)
Hank Beatty (Illini)
Collin Dixon (Illini)
Lake McRee (USC)

Rushing Yards

Waymond Jordan (USC)
Kaden Feagin (Illini)
Luke Altmyer (Illini)
Jayden Maiava (USC)

Passing Yards

Jayden Maiava (USC)
Luke Altmyer (Illini)
Best Betting Offers
Memorial Stadium
Memorial Stadium

Illini Rock Solid at Home

Illinois have rattled off three straight wins at Memorial Stadium. They are 8-2 in their last 10 home games, putting up 35.70 points on average and giving up 17.10.

USC are 4-6 in their last 10 games away from home, scoring 26.60 points per contest and conceding 28.90.

Last 10 Games W-L P PF PA O60.5 U60.5
Illinois logo Illinois Home Stats 8-2 52.80 35.70 17.10 2 8
USC logo USC Away Stats 4-6 55.50 26.60 28.90 3 7
  • W-L = Wins-Losses
  • P = Avg. Points
  • PF = Avg. Points For
  • PA = Avg. Points Against
  • O60.5 = Games Over 60.5 Points
  • U60.5 = Games Under 60.5 Points

Last 5 & H2H

Team Stats

Latest regular season and playoff games stats.

USC logo USC Stats
Illinois Fighting Illini logo Illinois Fighting Illini Stats
Moneyline
  • 8 wins and 2 defeats in the last 10 games
  • 4 wins and 6 defeats in the last 10 games on the road
Moneyline
  • 7 wins and 3 defeats in the last 10 games
  • 9 wins and 1 defeat in the last 10 home games
Point Spread
Point Spread
Total Points
Total Points

NCAAF Standings Select Season

Big Ten W L PF PA N. Pts Home Away Strk
Indiana 4 0 219 33 186 4-0 0-0 4W
Maryland 4 0 130 43 87 3-0 1-0 4W
Ohio State 3 0 121 16 105 3-0 0-0 3W
Oregon 4 0 203 37 166 3-0 1-0 4W
Penn State 3 0 132 17 115 3-0 0-0 3W
USC 4 0 210 81 129 3-0 1-0 4W
Washington 3 0 167 55 112 2-0 1-0 3W
Rutgers 3 1 167 96 71 3-1 0-0 1L
Nebraska 3 1 174 54 120 2-1 1-0 1L
Michigan State 3 1 137 115 22 3-0 0-1 1L
Michigan 3 1 140 71 69 2-0 1-1 2W
Iowa 3 1 132 58 74 2-0 1-1 2W
Illinois 3 1 145 85 60 2-0 1-1 1L
Minnesota 2 1 103 37 66 2-0 0-1 1L
Purdue 2 2 112 106 6 2-1 0-1 2L
Wisconsin 2 2 83 75 8 2-1 0-1 2L
Northwestern 1 2 59 64 -5 1-1 0-1 1L
UCLA 0 3 43 108 -65 0-2 0-1 3L
NCAAF Predictions
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